The Evidence Pyramid

The traditional evidence pyramid remains a useful heuristic device for evaluating scientific evidence in medicine and health care. The highest quality evidence in the top two levels of the pyramid is the most difficult to process. The lowest quality of evidence at the bottom two levels of the pyramid is the easiest to process. ThisContinue reading “The Evidence Pyramid”

Can Long-Covid be Cured with the Mind: Expert Patient or Nutty Professor?

Guest authored by Dr. Keith Geraghty I am a research fellow working from the University of Manchester Centre for Primary Care. A major focus of my work is on medically unexplained symptoms and illness. I promote evidence-based medicine and psychology, so like a detective, I spend a lot of my time discerning ‘good’ and ‘bad’Continue reading “Can Long-Covid be Cured with the Mind: Expert Patient or Nutty Professor?”

“Doctors can commit scientific fraud and financial fraud and not be punished”

Press Release by Dr Myhill concerning Dr Myhill’s Virtual Hearing 22 MARCH 2021 – vs ICO & GMC Doctors can commit scientific fraud and financial fraud and not be punished. This is the conclusion of Dr Sarah Myhill following her recent hearing vs the ICO and GMC. Dr Sarah Myhill tells us “That is officialContinue reading ““Doctors can commit scientific fraud and financial fraud and not be punished””

Another dollar, another day, another set of slides for Swiss Re

Research requires funds and universities have overhead costs. The contributions of the Wessely School to research on ME/CFS are described in earlier posts. Here I start a series of posts on the funding sources of the universities involved. Professor Sir Simon Wessely is the Regius Professor of Psychiatry, Director of King’s Centre for Military HealthContinue reading “Another dollar, another day, another set of slides for Swiss Re”

Dog whistle medicine and disability denial

Here I review the corporate connections of the Wessely School with the insurance industry. The picture featured above shows the cover of a book edited by Peter Halligan and Mansel Alyward alongside a similar cover from the UnumProvident annual report of 2002. Imaginary conversation Imagine the conversation, which must have gone something like this: UnumContinue reading “Dog whistle medicine and disability denial”

Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS

HYPOTHESIS AND THEORY ARTICLE Front. Med., 28 January 2021 | Dominic Stanculescu, Lars Larsson and Jonas Bergquist Under a Creative Commons license open access Here Dominic Stanculescu et al. advance the hypothesis that ‘maladaptive mechanisms’ that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Specifically, these mechanisms are: (a) suppression ofContinue reading “Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS”

MECFS: evidence for an autoimmune disease

Autoimmunity Reviews Volume 17, Issue 6, June 2018, Pages 601-609 Review: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease Franziska Sotzny et al., on behalf of the European Network on ME/CFS (EUROMEN) Under a Creative Commons license open access Highlights The pathogenesis of ME/CFS is multifactorial, and immunological and environmental factors play a role.•Continue reading “MECFS: evidence for an autoimmune disease”

ME/CFS and autoimmunity

The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs) Gerwyn Morris,  Michael Berk,  Piotr Galecki &  Michael Maes  Molecular Neurobiology volume 49, pages741–756(2014) Cite this article Abstract The World Health Organization classifies myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs) as a nervous system disease. Together with other diseases under the G93 heading, ME/cfs shares a triad of abnormalities involvingContinue reading “ME/CFS and autoimmunity”

ME/CFS and homeostatic drive

A Role for Homeostatic Drive in the Perpetuation of Complex Chronic Illness: Gulf War Illness and Chronic Fatigue Syndrome Travis J. A. Craddock , Paul Fritsch, Mark A. Rice Jr, Ryan M. del Rosario, Diane B. Miller, Mary Ann Fletcher, Nancy G. Klimas, Gordon Broderick Published: January 8, 2014 PLEASE NOTE: THIS VERSION OF THEContinue reading “ME/CFS and homeostatic drive”

ME/CFS: A natural history

HYPOTHESIS AND THEORY ARTICLE Front. Neurol., 11 August 2020 | How Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Progresses: The Natural History of ME/CFS Luis Nacul1,2, Shennae O’Boyle1*, Luigi Palla3,4, Flavio E. Nacul5, Kathleen Mudie1, Caroline C. Kingdon1, Jacqueline M. Cliff6, Taane G. Clark6, Hazel M. Dockrell6 and Eliana M. Lacerda1 1Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & TropicalContinue reading “ME/CFS: A natural history”